NTEGRA Life is a NanoLaboratory, integrating Atomic Force Microscope and inverted optical microscope with NA 0.55 condensers. It is used for biological and medical researches in physiological conditions.
NTEGRA Life consists of the measurement head and positioning stage.
The motorized measurement head contains a XYZ scanner (100x100x20 um) and is a fully automated system. For ease of use the NTEGRA Life provides automatic alignment of the Atomic Force Microscope (AFM) optical system. It allows one to operate it without manual adjusting the cantilever.
The motorized stage allows XY sample positioning on an area of 20 x 20 mm with 0.07 um step size. It has also an optional plug in module for mounting 100 um XY or Z scanners.
The stage contains additional motorized positioning of measuring head relative to the sample.
Two different sample holders that are supported; a universal holder for a Petri dish or microscope slide, or a sample holder for a perfusion liquid cell with inlets for gas and fluid flow.
Due to enhanced construction and sample access the NTEGRA Life supports optical microscopy modes such as: Fluorescence, Bright field, Dark field, DIC and Phase contrast and the AFM modes: AFM (Contact + Intermittent Contact), Lateral Force Microscopy, Adhesion Force Imaging, Force Modulation, Phase Imaging, nano manipulation, lithography and Force Distance curves.
The sample can also be viewed in Fluorescence mode simultaneously with the nanometer scaled landscape of the surface.
Technical specifications :
The NTEGRA Life is used in such scientific fields where nanoscale characteristics matter. It can be applied in biology, medical and pharmaceutical research and the food industry.
Applications :
- Molecular and cellular biology research
- Live cell research
- Microbiology and virus research
- Cell-cell and cell-substrate interactions
It can be used to study physiological conditions of living cells, organelles and bimolecular systems. Atomically-sharp probes of an AFM can be used as a tool for local treatments and single cell nanosurgery. Solution exchange and temperature control are optional items that can be provided. The AFM integrated with an optical microscope is a powerful multi technique platform for biological and medical scientific research. |
