NTEGRA Vita combines the strengths of the excellent SPM with perfect optical microscope for biological and medical applications.
From molecules to living organisms, NTEGRA Vita opens the window to the world of biology and biochemistry. Especially designed to integrate seamlessly with your optical microscope, NTEGRA Vita preserves the in situ environment so that you can observe, image and measure what is really there.
For conventional AFM biological imaging as well as biochemistry and bioorganic applications, NTEGRA Vita uses a unique sealed fluid cell which maintains an enclosed volume. Input/output pipes provide controlled flow of nutrient liquids and a heating element precisely maintains temperature, from room temperature to 60 °C, with an accuracy of ±0.005 °C (typically).
Need the ultimate in resolution? You need "scanning-by-sample", a mode in which a small sample is scanned with great precision under a fixed probe. Our engineers have developed a special little fluid cell specifically for this application. This cell is also helpful when using expensive chemicals.
From large format to ultrahigh resolution, NTEGRA Vita has a solution for your lab.
Measurements and analysis of probe-to-sample forces in pico- and nano- Newton range provide new insight into cellular properties. "Pushing" a cell with the probe then evaluating the cantilever deflection provides quantitative information about the cell turgidity, cytoskeleton network rigidity, and cellular matrix density. "Touching" the surface-bound receptor molecules with a ligand-coated probe quantifies molecular interaction forces. NTEGRA Vita low noise closed loop sensors afford unprecedented accuracy of both probe movement and force measurements.
Key features :
- Integration of SPM and methods of optical (fluorescent) microscopy
- Investigation of mechanical properties on the molecular and cellular
- A great choice of conditions for the investigation of living objects
Scanning probe microscopy |
| SPM methods |
in air & liquid |
AFM (contact + semi-contact + non-contact) / Lateral Force Microscopy / Adhesion Force Imaging/ Force Modulation/ Phase Imaging/ AFM Lithography (scratching)/ Force-Distance curves |
| in air only |
STM/ Magnetic Force Microscopy/ Electrostatic Force Microscopy / Scanning Capacitance Microscopy/ Kelvin Probe Microscopy/ Spreading Resistance Imaging/ Lithography: AFM (Current), STM |
Specifications :
*Scanning head can be configured to serve as a stand-alone device for specimens of unlimited sizes.
** 200 ?m scan range is possible with the unique DualScanT mode when scanning by sample and scanning by probe can be done simultaneously.
*** Built-in capacitive sensors have extremely low noise and any area down to 50x50 nm can be scanned with closed-loop control.
Optical microscopy :
* System upgrade is possible to convert it into a near-field optical microscope or a laser confocal microscope.
** Any additional objectives can be supplied optionally.
*** Can be performed without compromise in optical or AFM performance.
Applications :
- Contact AFM
- Semicontact AFM
- Lateral Force Imaging
- Adhesion Force Imaging
- Force Modulation Mode
- Phase Imaging Mode
- AFM Litography
Model NTEGRA Vita is designed for biological applications, for investigations of Proteins, DNA, viruses, bacteriums, tissues.
Optional features :
- Electrochemical AFM and STM investigations
- Scanning Near-field Optical Microscopy
- Confocal laser scanning microscope/spectroscopy
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